Discovery Pipeline Clinical Studies Pharmacodynamics

Publications 

Peer reviewed publications, that Curonz's Director, Dr Sieg has contributed to:

  1. F Lovisari, A Guarino, M Soukupova, C Falcicchia, S Ingusci, P Marino, M Thomas, F Sieg and M Simonato (2021. Anti-epileptogenic effect of NRP2945 in the pilocarpine model of temporal lobe epilepsy. Eur J Pharmacol 15; 901:174068.doi: 10.1016/j.ejphar.2021.174068.
  2. P. Winkler, F. Sieg and A. Buttstedt, (2018). Transcriptional Control of Honey Bee (Apis mellifera) Major Royal Jelly Proteins by 20-Hydroxyecdysone. Insects 2018 Sept 19, 9(3):1-10.
  3. G. Dezsi F. Sieg, M. Thomas, T. J. O’Brien, M. van der Hart and N. C Jones, (2017). Disease-modifying effects of Neural Regeneration Peptide 2945 in the GAERS model of absence epilepsy. Neurochemical Research 42(7): 2055-2064.
  4. F. Sieg, (2016). Mini-review of neural regeneration peptide in brain development. Journal of Stem Cell Research Therapy. 1(4)00025 DOI: 10.15406/jsrt.2016.00025
  5. A. Sajadian, F. Sieg et al., (2015). Anticonvulsive effect of Neural Regeneration Peptide 2945 on pentylene tetrazole induced seizures in rats. Neuropeptides – 49:15-23.
  6. A. T. Singh, J. A. Keelan, F. Sieg (2010). Regulation of trophoblast migration and survival by a novel neural regeneration peptide (NRP). RBM online accepted, 2010.
  7. M.J. Bickerdike, G.B. Thomas, D.C. Batchelor, E.S. Sirimanne, W. Leong, H. Lin, F. Sieg, J. Wen, M.A. Brimble, P.W. Harris, P.D. Gluckman (2009). NNZ-2566: A Gly-Pro-Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke. Journal of Neurological Sciences 278: 85-90.
  8. F. Sieg and A. Antonic (2007) Alternative Strategies in Neuroregeneration and Neurogenesis. Research signpost edition (book chapter). Editor: Valeria Sogos and Andrea Diana; pp: 27-58.
  9. T. Gorba, P. Bradoo, A. Antonic, K. Marvin, D.-X. Liu, P. Lobie, K. Reymann, P.D. Gluckman and F. Sieg (2006). Neural Regeneration Proteins are novel chemoattractive and survival promoting peptides. Experimental Cell Research 312:3060-3074.
  10. J. Guan, S. Mathai, F. Sieg, T. Gorba, M.A. Brimble, P.D. Gluckman (2005). Neuroprotective effects of diketopiperazines, potential clinical application of small cyclic form of neuropeptide following ischemic brain injury. Journal of Cerebral Blood Flow & Metabolism. 25, S54.
  11. P. Landgraf, F. Sieg, G. Meyer, P. Wahle, H.-C. Pape and M. R. Kreutz (2005). A maternal blood-borne factor promotes survival of the developing thalamus. FASEB J. 19: 225-227.
  12. M.A. Brimble, N.S. Trotter, P.W.R. Harris and F. Sieg (2005). Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-L-glutamic acid (GPE) modified at the alpha-carboxylic acid. Bioorganic & Medicinal Chemistry 13: 501-519.
  13. M.A. Brimble, N.S. Trotter, P.W.R. Harris and F. Sieg (2005). Synthesis and pharma- cological evaluation of side chain modified glutamic acid analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE). Bioorganic & Medicinal Chemistry13: 519-532.
  14. M.Y.H. Lai, M.A. Brimble, D.J. Callis, P.W.R. Harris, M. S. Levi and F. Sieg (2005). Synthesis and pharmacological evaluation of glycine-modified analogues of the neuro- protective agent glycyl-L-prolyl-L-glutamic acid (GPE). >Bioorganic & Medicinal Chemistry 13: 533-548.
  15. H.A. Sror, G. Tischendorf, F.Sieg, J.M. Schmitt and D.K. Hincha (2003). Cryoprotectin protects thylakoids during a freeze-thaw cycle by a mechanism involving stable membrane binding. Cryobiology 47: 191-203.
  16. W.E. Wilhemi, U.H. Schroeder, A. Benabdallah, F. Sieg, J. Breder and K.G. Reymann (2002). Organotypic brain-slice cultures from adult rats: approaches for a prolonged culture time. ATLA 30: 275-283.
  17. D.K. Hincha, B. Neukamm, H.A.M. Sror, F. Sieg, W. Weckwrath, M. Rueckels, V. Lullien-Pellerin, W. Schroeder and J.M. Schmitt (2001). Cabbage cryoprotectin is a member of the nonspecific plant lipid transfer protein gene family. Plant Physiology 125: 835-846.
  18. T. Budde, F. Sieg, K.-H. Braunewell, E. Gundelfinger, H.-C. Pape (2000). Calcium-induced calcium release maintains the relay mode of activity in thalamocortical cells. Neuron 26:483-492.
  19. F. Sieg, P. Wahle and H.-C.Pape (1999). Cellular reactivity to mechanical axonal injury in an organotypic in vitro model of neurotrauma . Journal of Neurotrauma 16: 1099-1115.
  20. F. Sieg, K. Obst, T. Gorba, B. Riederer, H.-C. Pape and P. Wahle (1998). Postnatal expression pattern of calcium-binding proteins in organotypic thalamic cultures and in the dorsal thalamus in vivo. Developmental Brain Research 110:83-95.
  21. D.K. Hincha, F. Sieg, I. Bakaltcheva, H. Köth and J.M. Schmitt (1996). Freeze-thaw damage to thylakoid membranes: specific protection by sugars and proteins. Book title: "Advances in low-temperature biology", Vol.3, chapter 4, JAI Press Inc.
  22. F. Sieg, W. Schröder, J.M. Schmitt and D.K. Hincha (1996). Purification and characterisation of a cryoprotective protein (cryoprotectin) from leaves of cold-acclimated cabbage. Plant Physiology 111: 215-221.
  23. F. Sieg, J.M. Schmitt and D.K. Hincha (1994). Cryoprotective leaf proteins: Purification and partial characterisation. Cryo-Letters 14: 1-15.