disease Targets 

Due to NRP2945’s regenerative properties, it has the potential to be efficacious for many central nervous system and eye diseases, especially with follow-up compound development to target large neurological diseases.

CNS Biology:

causes of cell death in acute and chronic CNS injuries or diseases

Figure 1: Classical cell death cascade after CNS injury that also includes convulsive and non-convulsive Status Epilepticus. NRP2945 has shown very promising neuroprotective and neural inhibitory circuit stabilising activity profiles causing seizure downregulation when administered at 24 hrs after Status Epilepticus infliction with pilocarpine / lithium treatment profiles.

"Pearl Chain" like Migration Diagram

The below diagram shows NRPs provoking a “pearl-chain”-like migration (arrows) over a few millimeters originating from the thalamic tissue heading towards neocortical tissue. The in vitro assay used postnatal rat CNS-derived brain slices cultivated on coverslips.

migrating from thalamus to the cortex

The unique properties of NRPs allow it to have efficacy in many CNS diseases and injuries. While we are currently targeting Lennox-Gastaut Syndrome as our first indication we aim to develop NRP2945 and its follow-up compound for many other indications.